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Efficacy Data: Response rate: 79% at 3 weeks (50% reduction in MADRS) Remission rate: 75% at 4 months (phase 2, open-label extension) MADRS change: -14.08 points (CYB003 16mg) vs -8.24 (placebo) at 3 weeks Time to response: 1-3 weeks Source Why it might interest you: Rapid onset, durable effect after single/few doses, minimal chronic side effects, different mechanism from standard antidepressants, no daily pill burden

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